This work will help researchers to understand the process of brain plasticity and how the brain could re-wire itself during foetal life. QBI newsletters Subscribe. Help QBI research Give now. Skip to menu Skip to content Skip to footer. Site search Search. Site search Search Menu. Corpus callosum.
Home The Brain Brain anatomy. X-linked lissencephaly with absent corpus callosum and ambiguous genitalia XLAG : clinical, magnetic resonance imaging, and neuropathological findings. Sherr, E. The ARX story epilepsy, mental retardation, autism, and cerebral malformations : one gene leads to many phenotypes. Kitamura, K. Mutation of ARX causes abnormal development of forebrain and testes in mice and X-linked lissencephaly with abnormal genitalia in humans.
Nature Genet. Demonstrates nicely the extent of CNS deficits in Arx -knockout mice disorders of neuronal migration, neuroblast proliferation and regional specification and identifies mutations in the orthologous gene in humans by matching the clinical phenotype.
Demyanenko, G. Abnormalities in neuronal process extension, hippocampal development, and the ventricular system of L1 knockout mice. Itoh, K. Brain development in mice lacking L1—L1 homophilic adhesion. Dupre, N. Hereditary motor and sensory neuropathy with agenesis of the corpus callosum.
Boettger, T. EMBO J. Mowat, D. Mowat—Wilson syndrome. An excellent review of a recently identified haploinsufficiency syndrome with AgCC and Hirschsprung disease. Zweier, C. Clinical and mutational spectrum of Mowat—Wilson syndrome. Dobyns, W. Absence makes the search grow longer. Genomic microarray analysis identifies candidate loci in patients with corpus callosum anomalies. Neurology 65 , — Schaefer, G.
The neuroimaging findings in Sotos syndrome. Hu-Lince, D. The Autism Genome Project: goals and strategies. Pharmacogenomics 5 , — Karayiorgou, M. Schizophrenia genetics: uncovering positional candidate genes. Baron-Cohen, S. The cognitive neuroscience of autism. Psychiatry 75 , — Chinnasamy, D. A case of schizophrenia with complete agenesis of the corpus callosum. Psychiatry 14 , — Rubert, G.
Ethanol exposure during embryogenesis decreases the radial glial progenitor pool and affects the generation of neurons and astrocytes. Evrard, S. Altered neuron—glia interactions in a low, chronic prenatal ethanol exposure. Brain Res.
Guerri, C. Glia and fetal alcohol syndrome. Neurotoxicology 22 , — Greenberg, D. Linking acquired neurodevelopmental disorders to defects in cell adhesion. Natl Acad. USA , — Minana, R. Alcohol exposure alters the expression pattern of neural cell adhesion molecules during brain development. Wilkemeyer, M. Roebuck, T. A review of the neuroanatomical findings in children with fetal alcohol syndrome or prenatal exposure to alcohol.
Alcohol Clin. The musician's brain as a model of neuroplasticity. Satoh, M. Left hemianomia of musical symbols caused by callosal infarction. Psychiatry 77 , — Schlaug, G. Increased corpus callosum size in musicians.
Neuropsychologia 33 , — Alvarez-Dolado, M. Regulation of the L1 cell adhesion molecule by thyroid hormone in the developing brain. Berbel, P. Role of thyroid hormones in the maturation of interhemispheric connections in rats. Maturation of visual callosal connections in visually deprived kittens: a challenging critical period.
Prenatal diagnosis of fetal corpus callosum agenesis by ultrasonography and magnetic resonance imaging. Shevell, M. Clinical and diagnostic profile of agenesis of the corpus callosum. Child Neurol. Goodyear, P. Outcome in prenatally diagnosed fetal agenesis of the corpus callosum. Fetal Diagn. Moutard, M. Agenesis of corpus callosum: prenatal diagnosis and prognosis. Childs Nerv. Through prenatal ultrasound identification and postnatal follow-up, this research shows that most individuals with AgCC either have early developmental delay or demonstrate learning deficits in school years, suggesting that asymptomatic AgCC individuals are probably rare.
Brown, W. Bilateral field advantage and evoked potential interhemispheric transmission in commissurotomy and callosal agenesis. Neuropsychologia 37 , — Compares IHT between individuals with AgCC, a person with a split-brain and controls, using both evoked potentials and bilateral field matching tasks. It demonstrates the limitations of interhemispheric transfer caused by corpus callosum absence. Interhemispheric Stroop effects in partial and complete agenesis of the corpus callosum. Jeeves, M.
Meerwaldt, J. Disturbances of spatial perception in a patient with agenesis of the corpus callosum. Neuropsychologia 21 , — Sauerwein, H. Intra- and inter-hemispheric processing of visual information in callosal agenesis. Lassonde, M. Dichotic listening, callosal agenesis and cerebral laterality. Brain Lang. The corpus callosum and cerebral speech lateralization. Kessler, J. Complex sensory cross integration deficits in a case of corpus callosum agenesis with bilateral language representation: Positron-Emission-Tomography and neuropsychological findings.
McAndrews, M. Language representation and sensory-motor mapping absent a corpus callosum. Neuroimage 13 , S Chiarello, C. A house divided? Cognitive functioning with callosal agenesis. Chiarello provides a summary of cognitive data from multiple published case studies and a meta-analysis of the psychology literature on AgCC as of Includes a meta-analysis of basic cognitive skills in AgCC, as well as seven fairly high-functioning individuals with AgCC borderline to low average IQ.
Neurocognitive patterns were examined and deficits in more subtle cognitive tasks were found. Brown, L. Hemispheric equivalence and age-related differences in judgments of simultaneity to somatosensory stimuli. David, A. Severe psychiatric disturbance and abnormalities of the corpus callosum: Review and case series. Aalto, S. Neuroanatomical substrata of amusement and sadness: a PET activation study using film stimuli. Neuroreport 13 , 67—73 Fischer, M.
Mechanisms of interhemispheric transfer and patterns of cognitive function in acallosal patients of normal intelligence. Imamura, T. Is disturbed transfer of learning in callosal agenesis due to a disconnection syndrome?
Solursh, L. The relationships of agenesis of the corpus callosum to perception and learning. Liederman, J.
Interhemispheric collaboration in response to simultaneous bilateral input. Neuropsychologia 23 , — Temple, C. Ten pen men: rhyming skills in two children with callosal agenesis. Reading in callosal agenesis. Banich, M. A life-span perspective on interaction between the cerebral hemispheres. Sanders, R. Sentence comprehension following agenesis of the corpus callosum. Phonemic discrimination in callosal agenesis. Cortex 29 , — Paralinguistic processing in children with callosal agenesis: emergence of neurolinguistic deficits.
Paul, L. Communicative deficits in agenesis of the corpus callosum: nonliteral language and affective prosody. It revealed a deficit in comprehension of second-order meanings in verbal communication.
Comprehension of humor in primary agenesis of the corpus callosum. Neuropsychologia 43 , — Huber-Okrainec, J. Idiom comprehension deficits in relation to corpus callosum agenesis and hypoplasia in children with spina bifida meningomylocele.
Buchanan, D. A proposed neurophysiological basis of alexithymia. O'Brien, G. Eckstein, K. It's early: event-related potential evidence for initial interaction of syntax and prosody in speech comprehension. Cogn Neurosci. Late interaction of syntactic and prosodic processes in sentence comprehension as revealed by ERPs. Friederici, A. Lateralization of auditory language functions: a dynamic dual pathway model.
Borod, J. Emotional processing deficits in individuals with unilateral brain damage. Josse, G. Hemispheric specialization for language. Tabibnia, G. Alexithymia, interhemispheric transfer, and right hemispheric specialization: a critical review.
Badaruddin, D. Social and behavioral problems of children with agenesis of the corpus callosum. Child Psychiatry and Hum. Cognitive and psychosocial deficits in agenesis of the corpus callosum with normal intelligence. This two-case study examined IHT, general cognition and social cognition in AgCC and outlines a theory linking the social deficits back to the anatomically-based deficits in IHT.
This theory is foundational to current neuropsychological studies of AgCC. Stickles, J. A year review of communication development in an individual with agenesis of the corpus callosum. Social processing deficits in agenesis of the corpus callosum: Narratives from the Thematic Apperception Test. Emotional arousal in agenesis of the corpus callosum. Happe, F. Time to give up on a single explanation for autism. Motomura, N. Monozygotic twin cases of the agenesis of the corpus callosum with schizophrenic disorder.
Psychiatry Clin. Hardan, A. Corpus callosum size in autism. Neurology 55 , — It is a large bundle of fibers that connects the left and right hemispheres, and it carries information received in one hemisphere over to the other. In the second half of the twentieth century, Roger Sperry, Michael Gazzaniga, and others studied patients whose corpus callosum had been severed in a procedure called a corpus callosotomy.
The procedure is normally undertaken as a last-resort treatment of epilepsy , as it can stop seizures from spreading from one hemisphere of the brain to another. The patients became known as split-brain patients. Surprisingly, a corpus callosotomy can be completed without severe side effects; the side effects that do appear are often language related. Sperry and Gazzaniga explored language deficits in callosotomy patients in detail. In the process, they learned some interesting things about how language centers are distributed across the cerebral hemispheres and how the corpus callosum facilitates communication between the two sides of the brain.
Sperry and Gazzaniga presented split-brain patients with visual stimuli, but only to one eye at a time. For example, they would present an image of a flower to the right eye, but cover the left eye.
They found that split-brain patients, when presented with a visual image to only their left eye, could not name the object shown in the image. Sperry and colleagues hypothesized that this occurred because visual information for the majority of the visual field travels to the opposite side of the brain to be processed. If the object is shown to the left eye, most of the information travels to the right side of the brain. Normally, this information would then be shared with the opposite hemisphere by way of the corpus callosum.
The researchers suggested that split-brain individuals could not name the object if it was shown only to the left eye because the visual information was not reaching the left side of the brain, which is where our important language centers are located. Much of what you've heard about one cerebral hemisphere being dominant in the management of a particular skill or capacity is probably exaggerated. For example, someone who is creative doesn't likely have an overall bias toward thinking with the right side of her brain.
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